Bayesian Study Design

This second whitepaper shows how the Bayesian framework is highly appropriate for planning and executing interim analyses:

• The rationale for using a Bayesian approach to interim analyses is explained.
• The formulation of interim decision rules on the basis of posterior and predictive probability is introduced and evaluated using a case study.
• The value of simulations are included to assess the merits of the different decision rules and the relative timing of interim analyses is illustrated.